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Also, the cyclic AMP-protein kinase signaling pathway that influences the expression and function of nuclear transcription factors such as c-fos, p53, AP-1, Sp1, and CREB (Ca2 + /cAMP response element-binding protein) involved in the transition from proliferation to differentiation of neural cells is impaired by organophosphates ( Studies on organophosphorus pesticides have focused the attention on neurons, which are considered to be the primary target for neurotoxicity (Won et al., 2001

Lynch DR, Farmer J, Hauser L, Blair IA, Wang QQ, Mesaros C, et al